Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
EN | CN

Product Inquiry: sales@probechem.com
Order/PO receiving: order@probechem.com

You are here:Home-Chemical Inhibitors & Agonists-NF-κB Pathway-IκB kinase (IKK)-iNUB
iNUB

Chemical Structure : iNUB

CAS No.: 352336-00-6

Add to Favorites

iNUB (Inhibitor of NEMO-Ub binding)

Catalog No.: PC-60552Not For Human Use, Lab Use Only.

iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote
250 mg Get quote
Get Quotation Now
* Please select Quantity before adding items.
 or Bulk Inquiry

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.
    iNUB binds to NEMO UBAN (ubiquitin binding domain (UBAN)) and competes for interaction with methionine-1-linked linear ubiquitin chains.
    iNUB inhibits UBAN-dependent NF-κB activation upon TNFα and TCR/CD28 stimulation, shows selective toxicity to IKK/NF-κB dependent ABC-DLBCL

    Physicochemical Properties

    M.Wt 384.387
    Formula C24H16O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl 2-phenylcyclopropane-1-carboxylate

    References

    1. Vincendeau M, et al. Sci Rep. 2016 Jan 7;6:18934.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: