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iNUB

Chemical Structure : iNUB

CAS No.: 352336-00-6

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iNUB (Inhibitor of NEMO-Ub binding)

Catalog No.: PC-60552Not For Human Use, Lab Use Only.

iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    iNUB (Inhibitor of NEMO-Ub binding) is a small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.
    iNUB binds to NEMO UBAN (ubiquitin binding domain (UBAN)) and competes for interaction with methionine-1-linked linear ubiquitin chains.
    iNUB inhibits UBAN-dependent NF-κB activation upon TNFα and TCR/CD28 stimulation, shows selective toxicity to IKK/NF-κB dependent ABC-DLBCL

    Physicochemical Properties

    M.Wt 384.387
    Formula C24H16O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    8-hydroxy-9,10-dioxo-9,10-dihydroanthracen-1-yl 2-phenylcyclopropane-1-carboxylate

    References

    1. Vincendeau M, et al. Sci Rep. 2016 Jan 7;6:18934.

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