Catalog No.: PC-61282Not For Human Use, Lab Use Only.
AS602868 (SPC-839) is a potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60 nM and Ki of 20 nM, also interfers directly with FLT3 kinase activation.
AS602868 (SPC-839) is a potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60 nM and Ki of 20 nM, also interfers directly with FLT3 kinase activation.
AS602868 displays no significant inhibitory activity for IKK1 and a large panel of recombinant kinases.
AS602868 prevents TNF-α induction of the antiapoptotic genes coding for c-IAP-2, Bclx, Bfl-1/A1 and Traf-1, induces cell death in Jurkat leukemic T cells.
