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Chemical Structure : AS602868
Catalog No.: PC-61282Not For Human Use, Lab Use Only.
AS602868 (SPC 839) is a potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60 nM and Ki of 20 nM, also interfers directly with FLT3 kinase activation.
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AS602868 (SPC 839) is a potent, selective and ATP-competitive inhibitor of IKK2 with IC50 of 60 nM and Ki of 20 nM, also interfers directly with FLT3 kinase activation.
AS602868 displays no significant inhibitory activity for IKK1 and a large panel of recombinant kinases.
AS602868 prevents TNF-α induction of the antiapoptotic genes coding for c-IAP-2, Bclx, Bfl-1/A1 and Traf-1, induces cell death in Jurkat leukemic T cells.
| M.Wt | 366.395 | |
| Formula | C18H14N4O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Frelin C, et al. Oncogene. 2003 Nov 6;22(50):8187-94.
2. Frelin C, et al. Blood. 2005 Jan 15;105(2):804-11.
3. Griessinger E, et al. Leukemia. 2007 May;21(5):877-85.
4. Jourdan M, et al. Br J Haematol. 2007 Jul;138(2):160-8.
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