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Chemical Structure : TBK1-IKKε inhibitor II
Catalog No.: PC-63015Not For Human Use, Lab Use Only.
TBK1-IKKε inhibitor II is a potent, selective dual inhibitor of TBK1/IKKε with IC50 of 13 nM/59 nM, respectively.
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TBK1-IKKε inhibitor II is a potent, selective dual inhibitor of TBK1/IKKε with IC50 of 13 nM/59 nM, respectively; displays 100- to 1000-fold less activity against other tested protein kinases including PDK1, PI3K family members and mTOR; inhibits LPS-induced expression of IFNβ (IC50=62 nM), and the IFNβ target genes IP10 (IC50=78 nM) and Mx1 (IC50=20 nM); effectively blocks TLR3-dependent IRF3 nuclear translocation in cells with IC50<100 nM.
| M.Wt | 533.633 | |
| Formula | C28H35N7O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Ou YH, et al. Mol Cell. 2011 Feb 18;41(4):458-70.
2. Hasan M, et al. J Immunol. 2015 Nov 15;195(10):4573-7.
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