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SU-909

Chemical Structure : SU-909

CAS No.: 2126749-48-0

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SU-909 (SU909;SU 909;IKKα-IN-48)

Catalog No.: PC-61066Not For Human Use, Lab Use Only.

SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    SU-909 (SU909, IKKα-IN-48) is a potent, selective IKKα inhibitor with Ki of 0.08±0.07 uM, 10-20-fold selectivity over IKKβ (IC50=1.0±0.28 uM).
    SU-909 inhibits FCS-stimulated phosphorylation of p100 in U2OS cells with IC50 of 8.8 uM, inhibits the noncanonical NF-kB pathway without affecting IKKβ-dependent IKappa-Bα loss in the canonical pathway.

    Physicochemical Properties

    M.Wt 314.323
    Formula C13H10N6O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(2-Amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-4-yl)benzenesulfonamide

    References

    1. Anthony NG, et al. J Med Chem. 2017 Aug 24;60(16):7043-7066.

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