IKK2-IN-8 | IKK2 inhibitor Probechem Biochemicals

Chemical Structure : IKK2-IN-8

IKK2-IN-8 (IKK2 inhibitor)

Catalog No.: PC-63117Not For Human Use, Lab Use Only.

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM).

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Biological Activity

IKK2-IN-8 is a potent, selective IKK2 inhibitor with IC50 of 6 nM, displays >40-fold selectivity over IKK1 (IC50=230 nM).
IKK2-IN-8 inhibits lipopolysaccharide (LPS) induced TNFα production in human PBMCs with IC50 of 80 nM.

Physicochemical Properties

M.Wt	380.47
Formula	C19H20N6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N-(1-(3-(8-methyl-5-(methylamino)-8H-imidazo[4,5-d]thiazolo[5,4-b]pyridin-2-yl)phenyl)ethyl)acetamide

References

1. Dyckman AJ, et al. Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6.

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