PIAA | TBK1/IKKε inhibitor | Probechem Biochemicals

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Chemical Structure : PIAA

PIAA (TBK1/IKKε inhibitor)

Catalog No.: PC-35736Not For Human Use, Lab Use Only.

PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

PIAA is a TBK1/IKKε inhibitor with IC50 of 0.40/1.07 uM, selectively accelerates proliferation of β-cells.
PIAA downregulates polyinosine:polycytidylic acid (poly I:C)-stimulated phosphorylation of interferon responsive factor-3 (IRF3), a substrate of TBK1/IKKε.
PIAA augments β-cell-specific proliferation by increasing cAMP levels and mTOR activity via PDE3.
PIAA improves glucose control and β-cell mass in the STZ-induced diabetic mouse model.

Physicochemical Properties

M.Wt	265.268
Formula	C16H11NO3
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3-phenylbenzo[c]isoxazol-5-yl)acrylic acid

References

1. Xu J, et al. Sci Rep. 2018 Oct 22;8(1):15587.

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