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SU1261

Chemical Structure : SU1261

CAS No.:

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SU1261 (SU 1261)

Catalog No.: PC-22934Not For Human Use, Lab Use Only.

SU1261 is a potent, selective inhibitor of IKKα with Ki of 10 nM, >60-fold selective over IKKβ.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

SU1261 is a potent, selective inhibitor of IKKα with Ki of 10 nM, >60-fold selective over IKKβ, selectively perturbs non-canonical NF-κB signalling whilst avoiding any significant impact upon the IKKβ-mediated canonical NF-κB pathway in cells.

Physicochemical Properties

M.Wt 431.50
Formula C27H21N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(2-(3-(benzyloxy)phenyl)-1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-indazol-3-amine

References

1. Christopher Riley, et al. Molecules. 2024 Jul 26;29(15):3515.

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