AZ13102909 | TBK1 inhibitor | Probechem Biochemicals

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Chemical Structure : AZ13102909

AZ13102909 (AZ909)

Catalog No.: PC-38528Not For Human Use, Lab Use Only.

AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AZ13102909 (AZ909) is a potent and selrctive TBK1 inhibitor with IC50 of 5 nM, 100-1000 fold greater for other related kinases.
AZ909 combines with AZD6244 to enhance apoptosis in AZD6244-resistant lines in 3D culture.

Physicochemical Properties

M.Wt	569.548
Formula	C28H37BrN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-((6-bromo-2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-3H-imidazo[4,5-b]pyridin-7-yl)amino)propyl)cyclopentanecarboxamide

References

1. Xu J, et al. Sci Rep. 2018 Oct 22;8(1):15587.

2. Vu HL, Molecular cancer research: MCR. 2014;12:1509–1519.

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AZ13102909 (AZ909)

Biological Activity

Physicochemical Properties

References

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