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Chemical Structure : AFN700
Catalog No.: PC-49484Not For Human Use, Lab Use Only.
AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM.
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AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM.
AFN700 also efficiently blocked IL-1b release triggered by nigericin in THP-1 cells with IC50 of 0.29 uM.
AFN700 blocked NLRP3-driven IL-1b production independently of NF-kB, blunted the competence of the NLRP3 inflammasome complex.
| M.Wt | 339.42 | |
| Formula | C19H22FN5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Adeline Unterreiner, et al. Biochem Biophys Res Commun. 2021 Mar 19;545:177-182.
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