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AFN700

Chemical Structure : AFN700

CAS No.: 778646-25-6

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AFN700 (AFN 700)

Catalog No.: PC-49484Not For Human Use, Lab Use Only.

AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AFN700 (AFN 700) is a specific inhibitor of IκKβ kinase with IC50 of 0.51 uM in NF-kB reporter gene assays, inhibits TNF-a secretion produced by THP-1 cells (3h treatment with 100 ng/ml Pam3CSK4) with IC50 of 0.89 uM.
    AFN700 also efficiently blocked IL-1b release triggered by nigericin in THP-1 cells with IC50 of 0.29 uM.
    AFN700 blocked NLRP3-driven IL-1b production independently of NF-kB, blunted the competence of the NLRP3 inflammasome complex.

    Physicochemical Properties

    M.Wt 339.42
    Formula C19H22FN5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((2R,6R)-2,6-dimethylpiperidin-4-yl)-4-(7-fluoro-1H-indol-3-yl)pyrimidin-2-amine

    References

    1. Adeline Unterreiner, et al. Biochem Biophys Res Commun. 2021 Mar 19;545:177-182.

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