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ACT-281959

Chemical Structure : ACT-281959

CAS No.: 1159501-31-1

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ACT-281959 (ACT281959;ACT 281959)

Catalog No.: PC-35578Not For Human Use, Lab Use Only.

ACT-281959 (ACT281959) is the prodrug of ACT-246475, which is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ACT-281959 (ACT281959) is the prodrug of ACT-246475, which is a potent, selective, reversible P2Y12 receptor antagonist with binding IC50 of 1.0 nM.
    ACT-281959 is orally acitve, shows efficacy in the rat ferric chloride thrombosis model.

    Physicochemical Properties

    M.Wt 850.86
    Formula C38H55N6O14P
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    butyl 4-((R)-3-(bis(((isopropoxycarbonyl)oxy)methoxy)phosphoryl)-2-(6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxamido)propanoyl)piperazine-1-carboxylate

    References

    1. Caroff E, et al. J Med Chem. 2015 Dec 10;58(23):9133-53.

    2. Rey M, et al. Pharmacol Res Perspect. 2017 Oct;5(5).

    3. Juif PE, et al. J Clin Pharmacol. 2018 Aug 8. doi: 10.1002/jcph.1296.

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