ACT-539313 | OX1R inhibitor | Probechem Biochemicals

Chemical Structure : ACT-539313

ACT-539313 (Nivasorexant, ACT539313)

Catalog No.: PC-21251Not For Human Use, Lab Use Only.

Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R.

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Biological Activity

Nivasorexant (ACT-539313) is a potent, selective and brain-penetrating orexin receptor type 1 receptor (OX1R) antagonist with Kb of 0.69 nM (human OX1R), 60-fold selective over OX2R.
Nivasorexant (ACT-539313) shows potential in the treatment of humans with binge-eating disorder.

Physicochemical Properties

M.Wt	429.48
Formula	C23H23N7O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	[4-Methyl-2-(2H-1,2,3-triazol-2-yl)phenyl][(3R)-3-[[3-(2H-1,2,3-triazol-2-yl)phenyl]methyl]-4-morpholinyl]methanone

References

1. Berger B, et al. J Clin Pharmacol. 2020 Jul;60(7):931-941.

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ACT-539313 (Nivasorexant, ACT539313)

Biological Activity

Physicochemical Properties

References

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