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Chemical Structure : ACT-660602
Catalog No.: PC-49265Not For Human Use, Lab Use Only.
ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.
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ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.
ACT-660602 displays high biological potency in inhibiting cell migration together with improvements of the metabolic stability and hERG issue.
ACT-660602 (30 mg/kg, q.d. po) significantly reduced recruitment of the CXCR3+ CD8+ T cell in the bronchoalveolar lavage compartment in LPS-induced lung inflammation model in mice.
| M.Wt | 534.485 | |
| Formula | C20H20F6N8OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Emmanuel A Meyer, et al. J Med Chem. 2022 Aug 10. doi: 10.1021/acs.jmedchem.2c00675.
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