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ACT-660602

Chemical Structure : ACT-660602

CAS No.: 1646267-59-5

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ACT-660602 (ACT660602)

Catalog No.: PC-49265Not For Human Use, Lab Use Only.

ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ACT-660602 (ACT660602) is a potent, selective and orally bioavailable CXCR3 antagonist with IC50 of 204 nM in human blood.
    ACT-660602 displays high biological potency in inhibiting cell migration together with improvements of the metabolic stability and hERG issue.
    ACT-660602 (30 mg/kg, q.d. po) significantly reduced recruitment of the CXCR3+ CD8+ T cell in the bronchoalveolar lavage compartment in LPS-induced lung inflammation model in mice.

    Physicochemical Properties

    M.Wt 534.485
    Formula C20H20F6N8OS
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-1-(2-methyl-4-(2-(trifluoromethyl)-4-(2-(trifluoromethyl)pyrimidin-5-yl)thiazol-5-yl)piperazin-1-yl)ethan-1-one

    References

    1. Emmanuel A Meyer, et al. J Med Chem. 2022 Aug 10. doi: 10.1021/acs.jmedchem.2c00675.

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