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Chemical Structure : ACT-672125
Catalog No.: PC-49264Not For Human Use, Lab Use Only.
ACT-672125 (ACT672125) is a potent, selective CXCR3 antagonist with IC50 of 239 nM in human blood.
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ACT-672125 (ACT672125) is a potent, selective CXCR3 antagonist with IC50 of 239 nM in human blood.
ACT-672125 showed good physicochemical properties and safety profile.
ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner in proof-of-mechanism model of lung inflammation.
| M.Wt | 586.598 | |
| Formula | C25H25F3N10O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Eva Caroff, et al. J Med Chem. 2022 Aug 15. doi: 10.1021/acs.jmedchem.2c00676.
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