ACT-777991 | CXCR3 inhibitor | Probechem Biochemicals

Chemical Structure : ACT-777991

CAS No.: 1967811-46-6

ACT-777991 (ACT777991)

Catalog No.: PC-20096Not For Human Use, Lab Use Only.

ACT-777991 (ACT777991) is a highly potent and selective CXCR3 antagonist with IC50 of 33 nM.

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2 mg	$258	In stock
5 mg	$428	In stock
10 mg	$728	In stock
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Biological Activity

ACT-777991 (ACT777991) is a highly potent and selective CXCR3 antagonist with IC50 of 33 nM.
ACT-777991 showed dose-dependent efficacy and target engagement in a mouse model of acute lung inflammation.

Physicochemical Properties

M.Wt	550.48
Formula	C20H20F6N8O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(2-(2-hydroxyethyl)-4-(2-(trifluoromethyl)-4-(2-(trifluoromethyl)pyrimidin-5-yl)thiazol-5-yl)piperazin-1-yl)-2-(3-methyl-1H-1,2,4-triazol-1-yl)ethan-1-one

References

1. Meyer EA, et al. J Med Chem. 2023 Mar 8. doi: 10.1021/acs.jmedchem.3c00074.

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ACT-777991 (ACT777991)

Biological Activity

Physicochemical Properties

References

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