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Chemical Structure : ADA-07
Catalog No.: PC-70142Not For Human Use, Lab Use Only.
ADA-07 is a novel potent TOPK inhibitor that effectively suppresses SUV-induced activation of MAPKs signal transduction resulting in reduced SUV-induced skin carcinogenesis.
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ADA-07 is a novel potent TOPK inhibitor that effectively suppresses SUV-induced activation of MAPKs signal transduction resulting in reduced SUV-induced skin carcinogenesis.
ADA-07 interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity.
ADA-07 suppresses SUV-induced phosphorylation of ERK1/2, p38, and JNKs, and subsequently inhibits AP-1 activity.
ADA-07 dramatically attenuates tumor incidence, multiplicity, and volume in SKH-1 hairless mice.
| M.Wt | 296.37 | |
| Formula | C18H20N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gao G, et al. Mol Cancer Ther. 2017 Jun 27. pii: molcanther.0212.2017.
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