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ADA-07

Chemical Structure : ADA-07

CAS No.: 2252153-94-7

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ADA-07 (ADA 07;ADA07)

Catalog No.: PC-70142Not For Human Use, Lab Use Only.

ADA-07 is a novel potent TOPK inhibitor that effectively suppresses SUV-induced activation of MAPKs signal transduction resulting in reduced SUV-induced skin carcinogenesis.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ADA-07 is a novel potent TOPK inhibitor that effectively suppresses SUV-induced activation of MAPKs signal transduction resulting in reduced SUV-induced skin carcinogenesis.
    ADA-07 interacts with TOPK at the ATP-binding pocket and inhibits its kinase activity.
    ADA-07 suppresses SUV-induced phosphorylation of ERK1/2, p38, and JNKs, and subsequently inhibits AP-1 activity.
    ADA-07 dramatically attenuates tumor incidence, multiplicity, and volume in SKH-1 hairless mice.

    Physicochemical Properties

    M.Wt 296.37
    Formula C18H20N2O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-5-(adamantan-1-yl)-3-(hydroxyimino)indolin-2-one

    References

    1. Gao G, et al. Mol Cancer Ther. 2017 Jun 27. pii: molcanther.0212.2017.

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