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ADAM17 inhibitor 2155-17

Chemical Structure : ADAM17 inhibitor 2155-17

CAS No.: 1802395-34-1

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ADAM17 inhibitor 2155-17

Catalog No.: PC-25431Not For Human Use, Lab Use Only.

ADAM17 inhibitor 2155-17 is a specific small molecule ADAM17 inhibitor with IC50 of 4.3 uM, with no activity against MMP2, MMP8, MMP9 ,MMP14, and ADAM10 (IC50>100 uM).

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ADAM17 inhibitor 2155-17 is a specific small molecule ADAM17 inhibitor with IC50 of 4.3 uM, with no activity against MMP2, MMP8, MMP9 ,MMP14, and ADAM10 (IC50>100 uM).

Physicochemical Properties

M.Wt 669.91
Formula C40H55N5O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-5-benzyl-1-((R)-1-cyclohexyl-3-((S)-2-(((S)-2,3-dioxo-6-propylpiperazin-1-yl)methyl)pyrrolidin-1-yl)propan-2-yl)-4-phenethylpiperazine-2,3-dione

References

1. Jaiswal AK, et al. Sci Rep. 2025 Aug 25;15(1):31253.

2. Knapinska AM, et al. J Med Chem. 2015 Aug 13;58(15):5808-24.

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