ADAM17 inhibitor SN-4

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Chemical Structure : ADAM17 inhibitor SN-4

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Catalog No.: PC-72743Not For Human Use, Lab Use Only.

ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ADAM17 inhibitor SN-4 is a novel specific inhibitor of A disintegrin and metalloproteinase 17 (ADAM17), inhibits TNF-α cleavage by SN-4 in cells with IC50 of 3.22 uM.
SN-4 showed slightly higher activity than the well-studied ADAM17 inhibitor marimastat.
SN-4 inhibited the ability of ADAM17 to cleave tumor necrosis factor α (TNF-α) in vitro, inhibited cleavage of CD44 by ADAM17, but not by ADAM10, and to suppress cell invasion.

Physicochemical Properties

M.Wt	508.714
Formula	C23H32N4O3S3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(but-2-yn-1-yloxy)-N-((4-(dimethylamino)-6-(((2-mercaptoethyl)amino)methyl)pyridin-2-yl)methyl)-N-(2-mercaptoethyl)benzenesulfonamide

References

1. Hiroshi Tateishi, et al. Chem Pharm Bull (Tokyo). 2021;69(11):1123-1130.

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