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ADS1017

Chemical Structure : ADS1017

CAS No.: 1383657-36-0

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ADS1017 (ADS-1017)

Catalog No.: PC-23592Not For Human Use, Lab Use Only.

ADS1017 is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ADS1017 is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.
ADS1017 demonstrates marked H3 receptor antagonist activity in the guinea pig jejunum functional assay (gpH3R pA2 = 8.21) and weak but competitive antagonism toward H1R with pA2 = 6.70.
ADS1017 shows a broad spectrum of analgesic activity in both nociceptive and neuropathic pain models.

Physicochemical Properties

M.Wt 479.71
Formula C29H45N5O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-benzyl-1-(4-(4-(7-phenoxyheptyl)piperazin-1-yl)butyl)guanidine

References

1. Karcz T, et al. ACS Chem Neurosci. 2024 Dec 9. doi: 10.1021/acschemneuro.4c00480.

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