AE90015 | mGlu5 NAM | Probechem Biochemicals

Chemical Structure : AE90015

AE90015 (AE-90015)

Catalog No.: PC-27666Not For Human Use, Lab Use Only.

AE90015 is a highly specific, effective negative allosteric modulator (NAM) for the human mGlu5 receptor (mGluR5), exhibiting an impressive affinity of 18.5 nM.

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Biological Activity

AE90015 is a highly specific, effective negative allosteric modulator (NAM) for the human mGlu5 receptor (mGluR5), exhibiting an impressive affinity of 18.5 nM.
AE90015 shows no significant efficacy or affinity for other mGlu receptors, including mGlu1, mGlu2, mGlu3, mGlu4, and mGlu7.
AE90015 shows significant promise for treating Parkinson's disease.

Physicochemical Properties

M.Wt	391.48
Formula	C22H25N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-methyl-N-(3-(picolinamido)adamantan-1-yl)pyrazine-2-carboxamide

References

1. Nasrallah C, et al. Cell Rep. 2021;36:109648.

2. Zou ZZ, et al. Molecules. 2024 Dec 4;29(23):5724.

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AE90015 (AE-90015)

Biological Activity

Physicochemical Properties

References

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