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Chemical Structure : AEF0117
Catalog No.: PC-20950Not For Human Use, Lab Use Only.
AEF0117 (AEF-0117) is a potent, signaling-specific inhibitor of the cannabinoid receptor 1 (CB1), inhibits the decrease in cellular respiration induced by THC (1 µM) in HEK293 cells transfected with hCB1 with IC50 of 3 nM.
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AEF0117 (AEF-0117) is a potent, signaling-specific inhibitor of the cannabinoid receptor 1 (CB1), inhibits the decrease in cellular respiration induced by THC (1 µM) in HEK293 cells transfected with hCB1 with IC50 of 3 nM.
AEF0117 inhibited Δ9-tetrahydrocannabinol (THC)-induced p-ERK1/2 in both cell lines with similar potency (IC50 300 nM) in CHO-hCB1 cells, and STHdhQ7/Q7 cells (mouse CB1).
AEF0117 (15 µg/kg) significantly reduced intravenous (i.v.) self-administration of the CB1 agonist WIN55,212-2 in CD-1 Swiss male mice and of THC in male squirrel monkeys.
AEF0117 (15 µg/kg) also inhibited THC-induced increases in nucleus accumbens (Nac) extracellular dopamine (DA) in freely moving rat.
AEF0117 inhibited the effects of THC related to cannabis addiction in vivo.
| M.Wt | 436.64 | |
| Formula | C29H40O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Margaret Haney, et al. Nat Med. 2023 Jun;29(6):1487-1499.
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