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Chemical Structure : AEF0117
CAS No.: 1610878-71-1
Catalog No.: PC-20950Not For Human Use, Lab Use Only.
AEF0117 (AEF-0117) is a potent, signaling-specific inhibitor of the cannabinoid receptor 1 (CB1), inhibits the decrease in cellular respiration induced by THC (1 µM) in HEK293 cells transfected with hCB1 with IC50 of 3 nM.
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| 10 mg | $118 | In stock | |
| 25 mg | $218 | In stock | |
| 50 mg | $358 | In stock | |
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AEF0117 (AEF-0117) is a potent, signaling-specific inhibitor of the cannabinoid receptor 1 (CB1), inhibits the decrease in cellular respiration induced by THC (1 µM) in HEK293 cells transfected with hCB1 with IC50 of 3 nM.
AEF0117 inhibited Δ9-tetrahydrocannabinol (THC)-induced p-ERK1/2 in both cell lines with similar potency (IC50 300 nM) in CHO-hCB1 cells, and STHdhQ7/Q7 cells (mouse CB1).
AEF0117 (15 µg/kg) significantly reduced intravenous (i.v.) self-administration of the CB1 agonist WIN55,212-2 in CD-1 Swiss male mice and of THC in male squirrel monkeys.
AEF0117 (15 µg/kg) also inhibited THC-induced increases in nucleus accumbens (Nac) extracellular dopamine (DA) in freely moving rat.
AEF0117 inhibited the effects of THC related to cannabis addiction in vivo.
| M.Wt | 436.64 | |
| Formula | C29H40O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
CC([C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OCC5=CC=C(OC)C=C5)CC[C@]4(C)[C@@]3([H])CC[C@]12C)=O |
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1. Margaret Haney, et al. Nat Med. 2023 Jun;29(6):1487-1499.
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