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AEPU

Chemical Structure : AEPU

CAS No.: 776300-69-7

AEPU

Catalog No.: PC-25595Not For Human Use, Lab Use Only.

AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AEPU is a moderately water soluble, orally-available, highly potent and selective soluble epoxide hydrolase (sEH) inhibitor with IC50 of 14 nM (human sEH), reduces the development of atherosclerosis in apolipoprotein e-knockout mouse model.

Physicochemical Properties

M.Wt 396.57
Formula C22H40N2O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

1-Adamantanyl-3-[5-[2-(2-ethoxyethoxy)ethoxy]pentyl]urea

References

1. Ulu A, et al. J Cardiovasc Pharmacol. 2008 Oct;52(4):314-23.

2. Liu JY, et al. Biochem Pharmacol. 2015 Dec 15;98(4):718-31.

3. Kim IH, et al. J Med Chem. 2007;50:5217–5226.

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