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AEP inhibitor 18

Chemical Structure : AEP inhibitor 18

CAS No.: 2978521-26-3

AEP inhibitor 18

Catalog No.: PC-21548Not For Human Use, Lab Use Only.

AEP inhibitor 18 is a potent, selective, orally bioavailable, and brain penetrant inhibitor of asparagine endopeptidase (AEP) with IC50 of 7.8 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AEP inhibitor 18 is a potent, selective, orally bioavailable, and brain penetrant inhibitor of asparagine endopeptidase (AEP) with IC50 of 7.8 nM.

Physicochemical Properties

M.Wt 455.41
Formula C21H21F4N3O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(2S,4R)-4-Fluoro-N-[(1S)-1-(2-amino-2-oxo-ethyl)prop-2-ynyl]-1-[1-[4-(trifluoromethoxy)phenyl]cyclopropanecarbonyl]pyrrolidine-2-carboxamide

References

1. Krummenacher D, et al. J Med Chem. 2023 Dec 13. doi: 10.1021/acs.jmedchem.3c01804.

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