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AF-353

Chemical Structure : AF-353

CAS No.: 865305-30-2

AF-353 (RO-4, AF353)

Catalog No.: PC-62754Not For Human Use, Lab Use Only.

AF-353 (RO-4) is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.0 and 7.1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AF-353 (RO-4) is a potent, selective and drug-like dual P2X3 and P2X2/3 antagonist with pIC50 of 8.0 and 7.1, respectively.

Physicochemical Properties

M.Wt 400.22
Formula C14H17IN4O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(5-iodo-2-isopropyl-4-methoxyphenoxy)pyrimidine-2,4-diamine

References

1. Jung YH, et al. ACS Chem Neurosci. 2017 Jul 19;8(7):1465-1478.

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