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AF-792

Chemical Structure : AF-792

CAS No.: 927872-24-0

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AF-792 (RO-5, AF792)

Catalog No.: PC-61827Not For Human Use, Lab Use Only.

AF-792 (RO-5) is a potent, selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AF-792 (RO-5) is a potent, selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors.
    AF-792 significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo.

    Physicochemical Properties

    M.Wt 298.346
    Formula C16H18N4O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-(5-ethynyl-2-isopropyl-4-methoxy-phenoxy)-pyrimidine-2,4-diamine

    References

    1. Carter DS, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31.

    2. Kaan TK, et al. J Neurosci. 2010 Mar 24;30(12):4503-7.

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