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Chemical Structure : AF-792
Catalog No.: PC-61827Not For Human Use, Lab Use Only.
AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors.
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AF-792 (RO-5) is a novel selective P2X3 and P2X2/3 antagonist with pIC50 of 8.2 and 7.9 respectively, with no inhibition at other P2X receptors; significantly inhibits micturition reflex activity, attenuates spinal activation of extracellular-signal regulated kinases (ERK) induced by acute peripheral stimulation of the bladder in vivo.
| M.Wt | 298.346 | |
| Formula | C16H18N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carter DS, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1628-31.
2. Kaan TK, et al. J Neurosci. 2010 Mar 24;30(12):4503-7.
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