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AF38469

Chemical Structure : AF38469

CAS No.: 1531634-31-7

AF38469 (AF-38469)

Catalog No.: PC-43219Not For Human Use, Lab Use Only.

AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AF38469 is a potent, selective, orally bioavailable Sortilin inhibitor with IC50 of 330 nM.
AF38469 shows no activity against the NTR1 receptor as well as a panel of targets known to bind acidic molecules (δ-Opioid, GPR40, PPARδ, EP1, Angiotensin AT1, Endothelin ETA/B, MMP-12).

Physicochemical Properties

M.Wt 324.2546
Formula C15H11F3N2O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 43 mg/mL

Chemical Name/SMILES

Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-

References

1. Schrøder TJ, et al. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80.

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