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Chemical Structure : AG-270
CAS No.: 2201056-66-6
Catalog No.: PC-72638Not For Human Use, Lab Use Only.
AG-270 (AG270) is a highly potent, selective, orally bioavailable MAT2A inhibitor with IC50 of 14 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $218 | In stock | |
| 10 mg | $358 | In stock | |
| 25 mg | $548 | In stock | |
| 50 mg | $898 | In stock | |
| 100 mg | Get quote |
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AG-270 (AG270) is a highly potent, selective, orally bioavailable methionine adenosyltransferase 2A (MAT2A) inhibitor with IC50 of 14 nM.
AG-270 demonstrated potent reduction in levels of intracellular SAM, as well as MTAP-null-selective antiproliferative activity in the HCT116 MTAP isogenic cell model in vitro ((IC50=20 nM).
AG-270 (200 mg/kg q.d.) dose-dependently reduced tumor SAM levels and tumor growthpancreatic KP4 MTAP-null xenograft mouse model.
AG-270 showed excellent microsomal, hepatocyte, and in vivo metabolic stability across species (human, mouse, rat, dog, and monkey).
| M.Wt | 489.579 | |
| Formula | C30H27N5O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
3-(cyclohex-1-en-1-yl)-6-(4-methoxyphenyl)-2-phenyl-5-(pyridin-2-ylamino)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
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1. Kalev P, et al. Cancer Cell. 2021 Feb 8;39(2):209-224.e11.
2. Konteatis Z, et al. J Med Chem. 2021 Apr 22;64(8):4430-4449.
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