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AG17724

Chemical Structure : AG17724

CAS No.: 884033-66-3

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AG17724 (Pin1 inhibitor DMS)

Catalog No.: PC-49154Not For Human Use, Lab Use Only.

AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in CAFs, leading to efficacious but transient tumor growth inhibition.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in cancer associated fibroblasts (CAFs), leading to efficacious but transient tumor growth inhibition.

    Physicochemical Properties

    M.Wt 377.38
    Formula C21H16FN3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-(2-Naphthamido)-3-(6-fluoro-1H-benzo[d]imidazol-2-yl)propanoic acid

    References

    1. Jiaye Liu, et al. Nat Commun. 2022 Jul 25;13(1):4308.

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