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AG17724

Chemical Structure : AG17724

CAS No.: 884033-66-3

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AG17724 (Pin1 inhibitor DMS)

Catalog No.: PC-49154Not For Human Use, Lab Use Only.

AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in CAFs, leading to efficacious but transient tumor growth inhibition.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AG17724 (Pin1 inhibitor DMS) is a selective inhibitor of prolyl isomerase Pin1 with Ki of 0.03 uM, DMS functionalized with CAF-targeting anti-FAP-α antibodies (antiCAFs-DMS) can selectively inhibit Pin1 in cancer associated fibroblasts (CAFs), leading to efficacious but transient tumor growth inhibition.

Physicochemical Properties

M.Wt 377.38
Formula C21H16FN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

References

1. Jiaye Liu, et al. Nat Commun. 2022 Jul 25;13(1):4308.

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