Catalog No.: PC-60649Not For Human Use, Lab Use Only.
AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization.
AG311 is a first-in-class antitumor and antimetastatic agent that induces necrosis in breast cancer tumors, inhibits inhibit mitochondria complex I activity and reduces HIF-1α stabilization.
AG311 induces rapid necrosis in numerous cancer cell lines (IC50=5.9-29.3 uM), also results in mitochondrial depolarization, superoxide production, and increased intracellular calcium levels.
AG311 does not increase apoptotic markers such as cleavage of PARP or caspase-3 and -7 activity, retards tumor growth and reduces lung metastases in breast cancer mouse models.
