You are here:Home-Chemical Inhibitors & Agonists-Others-Other Targets-AGF347
AGF347

Chemical Structure : AGF347

CAS No.: 2294820-23-6

AGF347 (AGF-347)

Catalog No.: PC-72124Not For Human Use, Lab Use Only.

AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM).

Packing Price Stock Quantity
25 mg Get quote
50 mg Get quote
100 mg Get quote

Bulk size, bulk discount!

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AGF347 (AGF-347) is a small molecule inhibitor targeting mitochondrial C1 metabolism at SHMT2 (in vitro Ki=2.19 uM), also directly targers the purine biosynthetic enzymes GARFTase (Ki=3.13 uM) and AICARFTase (Ki=3.72 uM), and SHMT1 (Ki=2.91 uM).
    AGF347 did not inhibit MTHFD2 at >200 uM.
    AGF347 demonstrated in vitro antitumor efficacies in a pancreatic cancer cell line panel (HPAC IC50=194 nM) and BxPC-3 (IC50=80 nM).
    AGF347 targeted SHMT2 in the mitochondria, and SHMT1 and the purine biosynthetic enzymes GARFTase and/or AICARFTase in the cytosol.
    AGF347 significant in vivo antitumor efficacy with potential for complete responses against both early-stage and upstage MIA PaCa-2 pancreatic tumor xenografts.

    Physicochemical Properties

    M.Wt 473.461
    Formula C22H24FN5O6
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4-(4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl)-2-fluorobenzoyl)-l-glutamic acid

    References

    1. Dekhne AS, et al. Mol Pharmacol. 2020 Jan;97(1):9-22.

    2. Dekhne AS, et al. Mol Cancer Ther. 2019 Oct;18(10):1787-1799.

    Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    Contact Us sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    Get Quote

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • Additional Information: