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AGI-25696

Chemical Structure : AGI-25696

CAS No.: 2201066-35-3

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AGI-25696 (AGI 25696)

Catalog No.: PC-72338Not For Human Use, Lab Use Only.

AGI-25696 (AGI 25696) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 97 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AGI-25696 (AGI 25696) is a potent and selective inhibitor of methionine adenosyltransferase MAT2A with IC50 of 97 nM.
    AGI-25696 reduces intracellular SAM levels in cancer cells, blocks the growth of MTAP-deleted tumors in vivo.

    Physicochemical Properties

    M.Wt 428.495
    Formula C28H20N4O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    5-methyl-2,3-diphenyl-6-(quinolin-6-yl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

    References

    1. Claudia De Fusco, et al. J Med Chem. 2021 May 27;64(10):6814-6826.

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