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You are here:Home-Chemical Inhibitors & Agonists-Nuclear Receptor/Transcription Factor-RAR/RXR-AGN-195183
AGN-195183

Chemical Structure : AGN-195183

CAS No.: 367273-07-2

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AGN-195183 (VTP-195183;NRX-195183, IRX-5183)

Catalog No.: PC-70122Not For Human Use, Lab Use Only.

AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.
AGN-195183 significantly reduces albuminuria and normalizes blood pressure, lowers glomerulosclerosis index, glomerular cell and interstitial cell counts, and area of the interstitial space in nephritic rats.
AGN-195183 reduces renal damage in rats with established chronic glomerulonephritis.

Physicochemical Properties

M.Wt 437.86
Formula C22H22ClF2NO4
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-[[(4-Chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-2,6-difluorobenzoic acid

References

1. Schaier M, et al. J Mol Med (Berl). 2004 Feb;82(2):116-25.

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