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Chemical Structure : AGN-195183
CAS No.: 367273-07-2
Catalog No.: PC-70122Not For Human Use, Lab Use Only.
AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $588 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM.
AGN-195183 significantly reduces albuminuria and normalizes blood pressure, lowers glomerulosclerosis index, glomerular cell and interstitial cell counts, and area of the interstitial space in nephritic rats.
AGN-195183 reduces renal damage in rats with established chronic glomerulonephritis.
| M.Wt | 437.86 | |
| Formula | C22H22ClF2NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[[(4-Chloro-5,6,7,8-tetrahydro-3-hydroxy-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]-2,6-difluorobenzoic acid |
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1. Schaier M, et al. J Mol Med (Berl). 2004 Feb;82(2):116-25.
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