| Cat. No. |
Product Name |
Information |
| PC-21838 |
KCL-286
RARβ agonist
|
KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively. |
| PC-21836 |
CD666
RARγ agonist
|
CD666 is a potent, selective RARgamma (RARγ) agonist. |
| PC-21835 |
CD2665
RARγ inhibitor
|
CD2665 is a potent, selective and orally active RAR-β/ RAR-γ antagonist with Ki of 306 and 110 nM, respectively. |
| PC-20775 |
IRX4204
RXR agonist
|
IRX4204 (AGN194204) is a potent, specific and brain penetrable pan-RXR agonist, fully activates all three RXRs (α, β and γ) at 1 nM, activates nuclear receptor Nurr1 downstream signaling. |
| PC-20433 |
Amsilarotene
RARα inhibitor
|
Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM. |
| PC-20205 |
AGN194310
pan-RAR inhibitor
|
AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM. |
| PC-20204 |
MM11253
RARγ inhibitor
|
MM11253 is a selective antagonist of retinoic acid receptor γ (RARγ) with IC50 of 44 nM. |
| PC-20200 |
ER-50891
RARα inhibitor
|
ER-50891 (ER50891) is a potent, selective antagonist of RARα receptor with IC50 of 31.2 nM, displays >300-fold selectivity over RARγ and RARβ. |
| PC-20199 |
LE135
RARβ inhibitor
|
LE135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Ki values=0.22 and 1.4 μM, respectively), highly selective over RARγ and RXRα. |
| PC-20198 |
BMS-195614
RARα inhibitor
|
BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding. |
| PC-49025 |
Ro41-5253
RARα antagonist
|
Ro 41-5253 is a potent and selective retinoic acid receptor-α (RARα) antagonist with IC50 of 16 nM. |
| PC-35992 |
Fenretinide
RAR agonist
|
Fenretinide (NSC 374551, 4-HPR, 4-Hydroxyphenyl retinamide) is a synthetic retinoid derivative with potential antineoplastic and chemopreventive activities, binds to and activates RARs, thereby inducing cell differentiation and apoptosis in some tumor cell types.. |
