Chemical Structure : Palovarotene
CAS No.: 410528-02-8
Catalog No.: PC-28143Not For Human Use, Lab Use Only.
Palovarotene (R-667, RO-3300074) is a potent, selective and orally active retinoic acid receptor-gamma (RAR-γ) agonist, inhibits bone morphogenetic protein and SMAD 1/5/8 signalling, prevents chondrogenesis and ultimately heterotopic ossification (HO) formation by permitting normal muscle tissue repair or regeneration to occur.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $138 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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Palovarotene (R-667, RO-3300074) is a potent, selective and orally active retinoic acid receptor-gamma (RAR-γ) agonist, inhibits bone morphogenetic protein and SMAD 1/5/8 signalling, prevents chondrogenesis and ultimately heterotopic ossification (HO) formation by permitting normal muscle tissue repair or regeneration to occur.
| M.Wt | 414.55 | |
| Formula | C27H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(E)-4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid |
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1. Hind M, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1243-50.
2. Lees-Shepard JB, et al. Elife. 2018 Sep 18;7:e40814.
3. Wheatley BM, et al. J Orthop Res. 2018 Apr;36(4):1135-1144.

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