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Palovarotene

Chemical Structure : Palovarotene

CAS No.: 410528-02-8

Palovarotene (R-667, RO-3300074, R667, RO3300074)

Catalog No.: PC-28143Not For Human Use, Lab Use Only.

Palovarotene (R-667, RO-3300074) is a potent, selective and orally active retinoic acid receptor-gamma (RAR-γ) agonist, inhibits bone morphogenetic protein and SMAD 1/5/8 signalling, prevents chondrogenesis and ultimately heterotopic ossification (HO) formation by permitting normal muscle tissue repair or regeneration to occur.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Palovarotene (R-667, RO-3300074) is a potent, selective and orally active retinoic acid receptor-gamma (RAR-γ) agonist, inhibits bone morphogenetic protein and SMAD 1/5/8 signalling, prevents chondrogenesis and ultimately heterotopic ossification (HO) formation by permitting normal muscle tissue repair or regeneration to occur.

Physicochemical Properties

M.Wt 414.55
Formula C27H30N2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(E)-4-(2-(3-((1H-pyrazol-1-yl)methyl)-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

References

1. Hind M, et al. Curr Opin Investig Drugs. 2009 Nov;10(11):1243-50.

2. Lees-Shepard JB, et al. Elife. 2018 Sep 18;7:e40814.

3. Wheatley BM, et al. J Orthop Res. 2018 Apr;36(4):1135-1144.

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