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Chemical Structure : KCL-286
Catalog No.: PC-21838Not For Human Use, Lab Use Only.
KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively.
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KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively.
KCL-286 (C286) displays 5-23 fold selectivity for RARβ over RARα (23 fold) and for RARβ over RARγ (5 fold) against the human RAR ligand-binding domains.
KCL-286 (C286) possess a promising pharmacokinetic profile in both rat and dog.
KCL-286 (C286) increases neurite outgrowth in vitro and induce sensory axon regrowth in vivo in a rodent model of avulsion and crush injury.
| M.Wt | 334.33 | |
| Formula | C19H14N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Maria B Goncalves, et al. Bioorg Med Chem Lett. 2019 Apr 15;29(8):995-1000.
2. Maria B Goncalves, et al. Br J Clin Pharmacol. 2023 Dec;89(12):3573-3583.
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