| Cat. No. |
Product Name |
Information |
| PC-70288 |
BMS-753
RARα agonist
|
BMS-753 (BMS753) is a potent, specific RARα agonist with Ki of 2 nM, displays no significant effects on RARγ in reporter based assays. |
| PC-70122 |
AGN-195183
RARα agonist
|
AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM. |
| PC-42609 |
AM580
RARα agonist
|
AM580 (CD336, NSC608001, Ro 40-6055) is an analog of retinoic acid that fuctions as a selective RARα agonist with EC50 of 0.3 nM. |
| PC-42316 |
AR7
RARα antagonist, CMA activator
|
AR7 (AR-7, AR 7) is a specific retinoid derivative that functions as a potent antagonist of RARα activity, specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy. |
| PC-24606 |
Bigelovin
RXR agonist
|
Bigelovin is a sesquiterpene lactone isolated from Inula hupehensis I and selective RXR agonist (EC50=4.9 uM), binds to RXRα-LBD with Kd of 8.7 uM. |
| PC-24566 |
Ellorarxine
RAR modulator
|
Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator. |
| PC-24565 |
HNF4 agonist 46
HNF4 agonist
|
HNF4 agonist 46 is a first-in-class, high-affinity hepatocyte nuclear factor 4 (HNF4) agonist, activates HNF4α (EC50=6 nM) and HNF4γ (EC50=17 nM) with low nanomolar potency, binds to HNF4α LBD with ITC Kd of 23 nM. |
| PC-24540 |
AS4040605
RARα inhibitor
|
AS4040605 is a novel retinoic acid receptor-α (RARα) inhibitor, suppresses IL2+IL33-induced IL-5 production in mouse type 2 innate lymphoid cells (ILC2s) with IC50 of 7.9 nM. |
| PC-23872 |
CBt-PMN
RXR partial agonist
|
CBt-PMN is a potent, selective retinoid X receptor (RXR) partial agonist with EC50 of 143 nM (RXRα, Emax = 75%), behaves similarly toward other RXR subtypes. |
| PC-23768 |
YCT-529
RARα antagonist
|
YCT-529 is a potent and selective RARα antagonist with IC50 of 6.8 nM, shows no activity against RARβ and RARγ up to 30 uM. |
| PC-23687 |
LG100268
RXR agonist
|
LG100268 (LG268) is a potent, selective, orally active retinoid X receptor (RXR) agonist with EC50 of 4 nM, 3 nM, and 4 nM for RXRα, RXRβ, and RXRγ, respectively. |
| PC-23686 |
LG100754
RXR homodimer antagonist
|
LG100754 (UVI 2112) is a specific antagonist of RXR homodimer also functions as a RXR:PPARα and RXR:PPARγ agonist. |
