| Cat. No. |
Product Name |
Information |
| PC-20830 |
LG101506
RXR modulator
|
LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM. |
| PC-20829 |
CD3254
RXR agonist
|
CD3254 (CD 3254) is a potent and selective RXR agonist with EC50 of 13 nM. |
| PC-20776 |
HX531
RXR antagonist
|
HX531 is a potent, pan RXR antagonist with IC50 of 18 nM on retinoidal activity in HL-60 cell assays, HX531 also is a partial PPARγ inhibitor and ameliorates diet-induced obesity and type 2 diabetes. |
| PC-20775 |
IRX4204
RXR agonist
|
IRX4204 (AGN194204) is a potent, specific and brain penetrable pan-RXR agonist, fully activates all three RXRs (α, β and γ) at 1 nM, activates nuclear receptor Nurr1 downstream signaling. |
| PC-20769 |
Bexarotene
RXR agonist
|
Bexarotene (LGD1069) is a highly potent and selective retinoid X receptors (RXR) agonist with EC50 of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ respectively, with no affinity for RAR receptors. |
| PC-20433 |
Amsilarotene
RARα inhibitor
|
Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM. |
| PC-20205 |
AGN194310
pan-RAR inhibitor
|
AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM. |
| PC-20204 |
MM-11253
RARγ inhibitor
|
MM11253 is a selective antagonist of retinoic acid receptor γ (RARγ) with IC50 of 44 nM. |
| PC-20200 |
ER-50891
RARα inhibitor
|
ER-50891 (ER50891) is a potent, selective antagonist of RARα receptor with IC50 of 31.2 nM, displays >300-fold selectivity over RARγ and RARβ. |
| PC-20198 |
BMS-195614
RARβ inhibitor
|
BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding. |
