AS4040605

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Chemical Structure : AS4040605

Catalog No.: PC-24540Not For Human Use, Lab Use Only.

AS4040605 is a novel retinoic acid receptor-α (RARα) inhibitor, suppresses IL2+IL33-induced IL-5 production in mouse type 2 innate lymphoid cells (ILC2s) with IC50 of 7.9 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AS4040605 is a novel retinoic acid receptor-α (RARα) inhibitor, suppresses IL2+IL33-induced IL-5 production in mouse type 2 innate lymphoid cells (ILC2s) with IC50 of 7.9 nM.
AS4040605 inhibited not only the increased production of IL-5 by RA stimulation but also the increased production of IL-5 by IL-2+IL-33 stimulation.
AS4040605 acts as an inverse agonist of RARα on ILC2s.

Physicochemical Properties

M.Wt	423.41
Formula	C20H18FN7O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(1-(5-(1-fluorocyclopropyl)-1-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1,2,4-triazine-3,5(2H,4H)-dione

References

1. Hara-Tsuchiya C, et al. Eur J Pharmacol. 2025 Apr 25;999:177682.

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AS4040605

Biological Activity

Physicochemical Properties

References

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