Bigelovin

Chemical Structure : Bigelovin

CAS No.: 3668-14-2

Catalog No.: PC-24606Not For Human Use, Lab Use Only.

Bigelovin is a sesquiterpene lactone isolated from Inula hupehensis I and selective RXR agonist (EC50=4.9 uM), binds to RXRα-LBD with Kd of 8.7 uM.

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5 mg	$188	In stock
10 mg	$298	In stock
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Biological Activity

Bigelovin is a sesquiterpene lactone isolated from Inula hupehensis I and selective RXR agonist (EC50=4.9 uM), binds to RXRα-LBD with Kd of 8.7 uM.
Bigelovin exerts inhibitory effects and triggers proteolysis of E2F1 in multiple myeloma cells.
Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells.
Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species.
Bigelovin efficiently inhibit a panel of cancer cells growth, including A549 (lung cancer), SGC-7901 (gastric cancer), BEL-7402 (liver cancer), U251 (glioma), B16 (murine melanoma), K562 (leukemia), and U937 (leukemia).

Physicochemical Properties

M.Wt	304.34
Formula	C17H20O5
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Azuleno[6,5-b]furan-2,5-dione, 4-(acetyloxy)-3,3a,4,4a,7a,8,9,9a-octahydro-4a,8-dimethyl-3-methylene-, (3aR,4S,4aR,7aR,8R,9aS)-

References

1. Li M, et al. Sci Rep. 2017 Feb 9;7:42176.

2. Zhang HH, et al. Acta Pharmacol Sin. 2015 Apr;36(4):507-16.

3. Zhang H, et al. J Mol Biol. 2011 Mar 18;407(1):13-20.

Bigelovin

Biological Activity

Physicochemical Properties

References

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