CBt-PMN

Chemical Structure : CBt-PMN

Catalog No.: PC-23872Not For Human Use, Lab Use Only.

CBt-PMN is a potent, selective retinoid X receptor (RXR) partial agonist with EC50 of 143 nM (RXRα, Emax = 75%), behaves similarly toward other RXR subtypes.

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Biological Activity

CBt-PMN is a potent, selective retinoid X receptor (RXR) partial agonist with EC50 of 143 nM (RXRα, Emax = 75%), behaves similarly toward other RXR subtypes.
CBt-PMN shows both PPARγ/RXRα and LXRα/RXRα agonistic activities in vitro.
CBt-PMN exhibits potent glucose-lowering effect and improvements of insulin secretion and glucose tolerance without the serious adverse effects caused by RXR full agonists.

Physicochemical Properties

M.Wt	363.46
Formula	C22H25N3O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Benzotriazole-5-carboxylic acid, 1-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-

References

1. Kakuta H, et al. ACS Med Chem Lett. 2012 Apr 9;3(5):427-32.

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CBt-PMN

Biological Activity

Physicochemical Properties

References

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