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Chemical Structure : AM580
CAS No.: 102121-60-8
Catalog No.: PC-42609Not For Human Use, Lab Use Only.
AM580 (CD336, NSC608001, Ro 40-6055) is an analog of retinoic acid that fuctions as a selective RARα agonist with EC50 of 0.3 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $118 | In stock | |
| 25 mg | $188 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | $458 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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AM580 (CD336, NSC608001, Ro 40-6055) is an analog of retinoic acid that fuctions as a selective RARα agonist with EC50 of 0.3 nM.
AM580 shows relatively weak agonist activity against RARβ and RARγ (EC50, 8.6 and 13 nM, respectively).
AM580 inhibits the proliferation of various tumor cells, inhibiting survival signaling pathways and inducing apoptosis.
AM580 efficiently induces differentiation of human IPSCs in combination with CHIR99021
| M.Wt | 351.4388 | |
| Formula | C22H25NO3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 45 mg/mL |
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| Chemical Name/SMILES |
Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbonyl]amino]- |
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1. Delescluse C, et al. Mol Pharmacol. 1991 Oct;40(4):556-62.
2. Kagechika H, et al. J Med Chem. 1988 Nov;31(11):2182-92.
3. Araoka T, et al. PLoS One. 2014 Jan 15;9(1):e84881.
4. Gianní M, et al. Blood. 1996 Feb 15;87(4):1520-31.
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