| Cat. No. |
Product Name |
Information |
| PC-70296 |
UVI 2008
RARβ/γ agonist, AKR1B10 inhibitor
|
UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM. |
| PC-70295 |
BMS-948
RARβ agonist
|
A RARβ-selective agonist that exhibits a full transcriptional agonistic activity and activating RARβ as efficiently as the reference agonist TTNPB. |
| PC-70294 |
BMS-189453
RARβ agonist, RARα/RARγ antagonist
|
BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ. |
| PC-70293 |
BMS-204493
RAR inverse agonist
|
BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM. |
| PC-70292 |
LE-540
RARβ antagonist
|
LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements. |
| PC-70289 |
CD 1530
RARγ agonist
|
CD 1530 is a potent and selective RARγ receptor agonist with Ki of 150 nM, >10-fold less potent for RARβ and RARα. |
| PC-70288 |
BMS-753
RARα agonist
|
BMS-753 (BMS753) is a potent, specific RARα agonist with Ki of 2 nM, displays no significant effects on RARγ in reporter based assays. |
| PC-70122 |
AGN-195183
RARα agonist
|
AGN-195183 (VTP-195183;NRX-195183, IRX-5183) is a potent, selective RARα agonist with binding Kd of 3 nM. |
| PC-42609 |
AM580
RARα agonist
|
AM580 (CD336, NSC608001, Ro 40-6055) is an analog of retinoic acid that fuctions as a selective RARα agonist with EC50 of 0.3 nM. |
| PC-42316 |
AR7
|
AR7 (AR-7, AR 7) is a novel retinoid derivative that functions as chemical activator on RARα activity. |
| PC-21838 |
KCL-286
RARβ agonist
|
KCL-286 (C286) is a potent, selective and orally bioavailable RARβ agonist with EC50 of 1.9 nM/26 nM/13 nM for RARβ/RARα/RARγ, respectively. |
| PC-21837 |
E6060
RARα agonist
|
E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays. |
