| Cat. No. |
Product Name |
Information |
| PC-20769 |
Bexarotene
RXR agonist
|
Bexarotene (LGD1069) is a highly potent and selective retinoid X receptors (RXR) agonist with EC50 of 33, 24, 25 nM for RXRα, RXRβ, and RXRγ respectively, with no affinity for RAR receptors. |
| PC-20433 |
Amsilarotene
RARα inhibitor
|
Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM. |
| PC-20205 |
AGN194310
pan-RAR inhibitor
|
AGN194310 (VTP-194310) is a highly potent, pan-RAR antagonist with binding Kd value of 2-5 nM, inhibits prostate carcinoma lines LNCaP, PC3 and DU145 with IC50 of 16-34 nM. |
| PC-20204 |
MM11253
RARγ inhibitor
|
MM11253 is a selective antagonist of retinoic acid receptor γ (RARγ) with IC50 of 44 nM. |
| PC-20200 |
ER-50891
RARα inhibitor
|
ER-50891 (ER50891) is a potent, selective antagonist of RARα receptor with IC50 of 31.2 nM, displays >300-fold selectivity over RARγ and RARβ. |
| PC-20199 |
LE135
RARβ inhibitor
|
LE135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Ki values=0.22 and 1.4 μM, respectively), highly selective over RARγ and RXRα. |
| PC-20198 |
BMS-195614
RARα antagonist
|
BMS-195614 (BMS614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM. |
| PC-49025 |
Ro41-5253
RARα antagonist
|
Ro 41-5253 is a potent and selective retinoic acid receptor-α (RARα) antagonist with IC50 of 16 nM. |
| PC-35992 |
Fenretinide
RAR agonist
|
Fenretinide (NSC 374551, 4-HPR, 4-Hydroxyphenyl retinamide) is a synthetic retinoid derivative with potential antineoplastic and chemopreventive activities, binds to and activates RARs, thereby inducing cell differentiation and apoptosis in some tumor cell types.. |
| PC-35622 |
UAB30
RXR agonist
|
UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis. |
| PC-35535 |
HX600
NURR1 (NR4A2) agonist
|
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers. |
| PC-35516 |
AC261066
RARβ2 agonist
|
AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
