| Cat. No. |
Product Name |
Information |
| PC-35516 |
AC261066
RARβ2 agonist
|
AC261066 (AC-261066, AC261) is a potent, selective, orally available RARβ2 agonist with pEC50 of 8.1, displays selectivity over RARβ1, RARα and RARγ (pEC50=6.4, 6.2 and 6.3). |
| PC-35171 |
Trifarotene
RARγ agonist
|
Trifarotene (CD5789, CD-5789) is a potent and selective RARγ agonist with EC50 of 7.7 nM, 500- and 125-fold selectivity over RARα and RARβ. |
| PC-63510 |
WYC-209
RAR agonist
|
WYC-209 is a novel synthetic retinoid that inhibits proliferation of malignant murine melanoma tumor-repopulating cells (TRCs) with IC50 of 0.19 uM, targets retinoic acid receptor (RAR). |
| PC-62836 |
LY-2955303
RARγ antagonist
|
LY-2955303 is a potent and selective RARγ antagonist with binding Ki of 1.09 nM, displays >1000-fold selectivity against RARα and RARβ. |
| PC-62291 |
CD 437
RARγ agonist
|
CD437 (CD 437) is a retinoid-like small molecule that selectively induces apoptosis in cancer cells, but not in normal cells, directly inhibits DNA polymerase α with IC50 of 22 nM, also acts as an RARγ agonist. |
| PC-70298 |
UVI-3003
RXR antagonist
|
UVI-3003 (UVI 3003) is a full antagonist of RXR that demonstrates potent, nanomolar binding affinity, inhibits xenopus and human RXRα in Cos7 cells with IC50 of 0.22 and 0.24 uM, respectively. |
| PC-70297 |
SR-11237
RXR agonist
|
SR-11237 (BMS-649) is a selective pan retinoid X receptor (RXR) agonist with no retinoid A receptor (RAR) activity. |
| PC-70296 |
UVI 2008
RARβ/γ agonist, AKR1B10 inhibitor
|
UVI 2008 is a RARβ/γ agonist originated from TTNPB, is also a selective inhibitor of aldo-keto reductase family member 1B10 (AKR1B10) with IC50 of 6.1 uM. |
| PC-70295 |
BMS-948
RARβ agonist
|
A RARβ-selective agonist that exhibits a full transcriptional agonistic activity and activating RARβ as efficiently as the reference agonist TTNPB. |
| PC-70294 |
BMS-189453
RARβ agonist, RARα/RARγ antagonist
|
BMS-189453 (BMS189453, BMS453) is a synthetic retinoid that acts as an agonist of RARβ and an antagonist of RARα and RARγ. |
| PC-70293 |
BMS-204493
RAR inverse agonist
|
BMS-204493 (BMS493) is a potent, pan-RAR inverse agonist that blocks RARα activity with IC50 of 114 nM. |
| PC-70292 |
LE-540
RARβ antagonist
|
LE-540 (LE540) is a potent, selective RARβ antagonist that inhibits RA-induced transcriptional activation of RARβ, but not RARα, RARγ or RXRα on a variety of RA response elements. |
