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Chemical Structure : Amsilarotene
CAS No.: 125973-56-0
Catalog No.: PC-20433Not For Human Use, Lab Use Only.
Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM.
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| 5 mg | $138 | In stock | |
| 10 mg | $218 | In stock | |
| 25 mg | $378 | In stock | |
| 50 mg | $558 | In stock | |
| 100 mg | Get quote |
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Amsilarotene (TAC-101) is a retinobenzoic acid with potential antineoplastic activity, shows selective affinity for RARα with binding Ki of 2.4 nM.
Amsilarotene inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest.
Amsilarotene also causes a cytotoxic decline in cyclin A and thymidylate synthase expression.
Amsilarotene induces the apoptotic of human gastric cancer, hepatocellular carcinoma and ovarian carcinoma cells.
| M.Wt | 385.61 | |
| Formula | C20H27NO3Si2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-[3,5-Bis(trimethylsilyl) benzamido] benzoic acid |
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1. Rizvi NA, et al. J Clin Oncol. 2002 Aug 15;20(16):3522-32.
2. Sakukawa R, et al. Oncol Res. 1998;10(6):287-93.
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