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Chemical Structure : LE135
CAS No.: 155877-83-1
Catalog No.: PC-20199Not For Human Use, Lab Use Only.
LE135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Ki values=0.22 and 1.4 μM, respectively), highly selective over RARγ and RXRα.
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LE135 is a retinoic acid receptor (RAR) antagonist that displays moderate selectivity for RARβ over RARα (Ki values=0.22 and 1.4 μM, respectively), highly selective over RARγ and RXRα.
LE135 inhibited retinoic acid (RA)-induced transcriptional activation of RARbeta, but not RARalpha, RARgamma or retinoid X receptor alpha (RXRalpha), on a variety of RA response elements.
LE135 inhibited all-trans-RA-induced apoptosis in ZR-75-1 human breast cancer cells.
| M.Wt | 438.57 | |
| Formula | C29H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid |
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1. Li Y, et al. J Biol Chem. 1999 May 28;274(22):15360-6.
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