Chemical Structure : HX600
CAS No.:
172705-89-4
HX600
(HX-600;HX 600)
Catalog No.: PC-35535Not For Human Use, Lab Use Only.
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.
HX600 effectively induces only carnitine palmitoyltransferase 1A (CPT1A) in human teratocarcinoma NT2/D1 cells, which express RXRα, Nur77 and NURR1.
HX600 also increases CPT1A expression in human embryonic kidney (HEK) 293 cells and hepatocyte-derived HepG2 cells.
HX600 reduces microglia expressed proinflammatory mediators and prevents inflammation induced neuronal death in in vitro co-culture model of neurons and microglia, prevents ischemia-induced neuronal damage in vivo.
Physicochemical Properties
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M.Wt
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438.571
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Formula
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C29H30N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20 °C 12 Months; 4°C 6 Months
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- In Solvent
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-80 °C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-(5,7,7,10,10-pentamethyl-7,8,9,10-tetrahydro-5H-benzo[b]naphtho[2,3-e][1,4]diazepin-12-yl)benzoic acid
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References
1. Loppi S, et al. Brain Behav Immun. 2018 Jul 29. pii: S0889-1591(18)30368-4.
2. Ishizawa M, et al. Biochem Biophys Res Commun. 2012 Feb 24;418(4):780-5.
3. Morita K, et al. Biochem Pharmacol. 2005 Dec 19;71(1-2):98-107.
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