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Chemical Structure : HX600
Catalog No.: PC-35535Not For Human Use, Lab Use Only.
HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.
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HX600 (HX-600) is a synthetic agonist of RXR-Nurr1 heterodimer complex, also selectively activate NGFI-B/RXR heterodimers.
HX600 effectively induces only carnitine palmitoyltransferase 1A (CPT1A) in human teratocarcinoma NT2/D1 cells, which express RXRα, Nur77 and NURR1.
HX600 also increases CPT1A expression in human embryonic kidney (HEK) 293 cells and hepatocyte-derived HepG2 cells.
HX600 reduces microglia expressed proinflammatory mediators and prevents inflammation induced neuronal death in in vitro co-culture model of neurons and microglia, prevents ischemia-induced neuronal damage in vivo.
| M.Wt | 438.571 | |
| Formula | C29H30N2O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Loppi S, et al. Brain Behav Immun. 2018 Jul 29. pii: S0889-1591(18)30368-4.
2. Ishizawa M, et al. Biochem Biophys Res Commun. 2012 Feb 24;418(4):780-5.
3. Morita K, et al. Biochem Pharmacol. 2005 Dec 19;71(1-2):98-107.
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