BMS-195614 | RARα inhibitor | Probechem Biochemicals

Chemical Structure : BMS-195614

BMS-195614 (BMS 614, BMS195614)

Catalog No.: PC-20198Not For Human Use, Lab Use Only.

BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding.

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Biological Activity

BMS-195614 (BMS195614) is a selective antagonist of neutral retinoic acid receptor RARα with Ki of 2.5 nM, antagonizes agonist-induced coactivator recruitment and moderately decreases SMRT binding to RAR, but does not significantly affect nuclear receptor corepressor binding.

Physicochemical Properties

M.Wt	448.52
Formula	C29H24N2O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(5,5-dimethyl-8-(quinolin-3-yl)-5,6-dihydronaphthalene-2-carboxamido)benzoic acid

References

1. M Géhin, et al. Chem Biol. 1999 Aug;6(8):519-29.

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BMS-195614 (BMS 614, BMS195614)

Biological Activity

Physicochemical Properties

References

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