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UAB30

Chemical Structure : UAB30

CAS No.: 205252-59-1

UAB30 (9cUAB30)

Catalog No.: PC-35622Not For Human Use, Lab Use Only.

UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.

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    Biological Activity

    UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.
    UAB30 decreases cellular proliferation, invasion and migration, cell-cycle arrest, and increases apoptosis in xenograft tumor growth in neuroblastoma.
    UAB30 prevents N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity.

    Physicochemical Properties

    M.Wt 294.394
    Formula C20H22O2
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    2,4,6-Octatrienoic acid, 8-(3,4-dihydro-1(2H)-naphthalenylidene)-3,7-dimethyl-, (all-E)-

    References

    1. Atigadda VR, et al. J Med Chem. 2003 Aug 14;46(17):3766-9.

    2. Hansen NJ, et al. Int J Oncol. 2007 Mar;30(3):641-50.

    3. Vedell PT, et al. Mol Pharmacol. 2013 Mar;83(3):698-708.

    4. Waters AM, et al. Mol Cancer Ther. 2016 May;15(5):911-21.

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