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Chemical Structure : UAB30
Catalog No.: PC-35622Not For Human Use, Lab Use Only.
UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.
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UAB30 (9cUAB30) is a novel synthetic rexinoid that binds selectively to the retinoid X receptor (RXR) leading to activation of genes involved in induction of differentiation and apoptosis.
UAB30 decreases cellular proliferation, invasion and migration, cell-cycle arrest, and increases apoptosis in xenograft tumor growth in neuroblastoma.
UAB30 prevents N-methyl-N-nitrosourea induced mammary cancers in rats without signs of toxicity.
| M.Wt | 294.394 | |
| Formula | C20H22O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Atigadda VR, et al. J Med Chem. 2003 Aug 14;46(17):3766-9.
2. Hansen NJ, et al. Int J Oncol. 2007 Mar;30(3):641-50.
3. Vedell PT, et al. Mol Pharmacol. 2013 Mar;83(3):698-708.
4. Waters AM, et al. Mol Cancer Ther. 2016 May;15(5):911-21.
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