Catalog No.: PC-42316Not For Human Use, Lab Use Only.
AR7 (AR-7, AR 7) is a specific retinoid derivative that functions as a potent antagonist of RARα activity, specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
AR7 (AR-7, AR 7) is a specific retinoid derivative that functions as a potent antagonist of RARα activity, specifically activates chaperone-mediated-autophagy (CMA) activity without affecting macroautophagy.
AR7 shows no significant agonist or antagonist activity on RXR.
AR7 activate CMA through RARα signaling and not by direct interaction with CMA components in lysosomes.
Physicochemical Properties
M.Wt
257.71488
Formula
C15H12ClNO
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
2H-1,4-Benzoxazine, 7-chloro-3-(4-methylphenyl)-
References
1. Anguiano J, et al. Nat Chem Biol. 2013 Jun;9(6):374-82.
