Chemical Structure : Ellorarxine
CAS No.:
2488822-99-5
Ellorarxine
(DC645, NVG0645)
Catalog No.: PC-24566Not For Human Use, Lab Use Only.
Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
Ellorarxine (DC645, NVG0645) is a synthetic retinoic acid and mimic of all-trans-retinoic acid, and a potent, CNS-permeable RAR modulator.
Ellorarxine upregulates expression of Cyp26b1 and RARβ.
Ellorarxine caused RARα in C6 cells to migrate towards one pole of the nucleus and RARγ in differentiated SH-SY5Y neurons to migrate towards the cell membrane.
Ellorarxine pretreatment alleviates mitochondrial dysfunction in SH-SY5Y cells, reduces cell death.
Ellorarxine selectively modulated microglia inflammatory cytokine release, also displays both antioxidant and anti-inflammatory effects.
Ellorarxine displays a wide-range of positive effects in a commonly used in vitro SOD1G93A NSC-34 mouse cell model of ALS
Physicochemical Properties
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M.Wt
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334.42
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Formula
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C21H22N2O2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxalinyl)ethynyl]benzoic acid
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References
1. Escudier O, et al. Int J Mol Sci. 2024 Sep 10;25(18):9764.
2. Zhang Y, et al. Int J Mol Sci. 2025 Apr 10;26(8):3551.
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