TLX agonist 2

Chemical Structure : TLX agonist 2

Catalog No.: PC-27592Not For Human Use, Lab Use Only.

TLX agonist 2 (Compound 31) is a small molecule agonist of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 0.1 uM and Kd of 0.16 uM, potentiates TLX transcriptional repressive activity.

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Biological Activity

TLX agonist 2 (Compound 31) is a small molecule agonist of orphan nuclear receptor tailless (TLX, NR2E1) with EC50 of 0.1 uM and Kd of 0.16 uM, potentiates TLX transcriptional repressive activity.

Physicochemical Properties

M.Wt	453.43
Formula	C23H18F3N5O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3-(1,5-dimethyl-1H-pyrazole-3-carboxamido)-5-(trifluoromethyl)phenyl)quinoline-4-carboxamide

References

1. Hank EC, et al. J Med Chem. 2026 Jun 25;69(12):14704-14721.

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TLX agonist 2

Biological Activity

Physicochemical Properties

References

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