Chemical Structure : AGS8-IN-1
CAS No.:
331244-90-7
AGS8-IN-1
Catalog No.: PC-26054Not For Human Use, Lab Use Only.
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AGS8-IN-1 is a small molecule inhibitor of activator of G-protein signaling 8 (AGS8), effectively inhibits the formation of the AGS8-Gβγ complex, attenuates VEGF-induced phosphorylation of signaling molecules and inhibits tube formation and migration of HUVECs.
AGS8-IN-1 inhibits the growth of AGS8-expressing yeast in a dose-dependent manner with IC50 of 20 uM.
AGS8-IN-1 blocks the interaction between AGS8C and Gβγ.
AGS8-IN-1 attenuates the phosphorylation of VEGFR2.
AGS8-IN-1 attenuates VEGF-mediated tube formation and migration of HUVECs.
Physicochemical Properties
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M.Wt
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491.54
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Formula
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C23H17N5O4S2
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-[2-[3-methyl-5-oxo-1-(4-phenyl-1,3-thiazol-2-yl)pyrazol-4-ylidene]hydrazinyl] naphthalene-1-sulfonic acid
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References
1. Hossain A, et al. J Physiol Sci. 2026 Feb 3;76(1):100064.
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