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AGX51

Chemical Structure : AGX51

CAS No.: 330834-54-3

AGX51 (AGX-51)

Catalog No.: PC-72578Not For Human Use, Lab Use Only.

AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
AGX51 induces ubiquitin-mediated degradation of Ids, cell growth arrest, and reduced viability.
AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization.
AGX51+aflibercept combination treatment worked better than aflibercept alone.
AGX51 as an anti-neovascular agent is likely due to its effects on blocking cell proliferation and vascular network disruption.

Physicochemical Properties

M.Wt 429.56
Formula C28H31NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Month
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-Benzyl-N-(3-(2,3-dihydrobenzofuran-6-yl)-3-(2-methoxyphenyl)propyl)propionamide

References

1. Wojnarowicz PM, et al. Cell Rep. 2019 Oct 1;29(1):62-75.e7.

2. Wojnarowicz PM, et al. NPJ Breast Cancer. 2021 May 24;7(1):58.

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