Catalog No.: PC-72578Not For Human Use, Lab Use Only.
AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
AGX51 is a small-molecule antagonist of Id helix-loop-helix (HLH) proteins (Id1-4), inhibits the Id1-E47 interaction, leading to ubiquitin-mediated degradation of Ids.
AGX51 induces ubiquitin-mediated degradation of Ids, cell growth arrest, and reduced viability.
AGX51 is well-tolerated in mice and phenocopies the genetic loss of Id expression in AMD and ROP models by inhibiting retinal neovascularization.
AGX51+aflibercept combination treatment worked better than aflibercept alone.
AGX51 as an anti-neovascular agent is likely due to its effects on blocking cell proliferation and vascular network disruption.
